Immunogen sequence: PALTSWPSLL GDMLADAINC LGFTWASSPA CTELEMNVMD WLAKMLGLPE HFLHHHPSSQ GGGVLQSTVS ESTLIALLAA RKNKILEMKT SEPDADESCL NARLVAYASD QAHSSVEK
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 94%.
The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; EC 188.8.131.52). This homodimeric enzyme is a pyridoxal phosphate (PLP)-dependent decarboxylase and is highly specific for its histidine substrate.
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Protein Aliases: HDC; Histidine decarboxylase; MGC163399
Gene Aliases: HDC
UniProt ID: (Human) P19113
Entrez Gene ID: (Human) 3067