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Invitrogen
HEC1 Polyclonal Antibody
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Product Details
PA5-18089
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (YEKKATLIKSSEE) corresponding to the C-terminus amino acids of NDC80 (aa 630-642).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HEC-1; HEC2; HEC4; Highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; kinetochore associated 2; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; nuclear protein; Retinoblastoma-associated protein HEC; unnamed protein product
Gene Aliases: HEC; HEC1; HsHec1; hsNDC80; KNTC2; NDC80; TID3
UniProt ID: (Human) O14777
Entrez Gene ID: (Human) 10403
mitotic sister chromatid segregation
establishment of mitotic spindle orientation
mitotic cell cycle
nuclear division
spindle organization
mitotic spindle organization
spindle assembly involved in female meiosis I
chromosome segregation
mitotic spindle assembly checkpoint
meiotic G2/MI transition
attachment of spindle microtubules to kinetochore
skeletal muscle satellite cell proliferation
regulation of protein stability
chromosome organization
centrosome duplication
cell division
metaphase plate congression
attachment of mitotic spindle microtubules to kinetochore
kinetochore organization
positive regulation of mitotic cell cycle spindle assembly checkpoint
nuclear chromosome segregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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