|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids and of Human HEC1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29186 targets HEC1 in WB applications and shows reactivity with Human samples.
The PA5-29186 immunogen is recombinant protein fragment corresponding to a region within amino acids and of Human HEC1.
HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HEC; HEC1; highly expressed in cancer; Highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore complex component; Kinetochore protein Hec1; Kinetochore protein NDC80 homolog; Kinetochore-associated protein 2; KNTC2; NDC80 homolog; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; Retinoblastoma-associated protein HEC; rich in leucine heptad repeats; TID3
Gene Aliases: HEC; HEC1; HsHec1; hsNDC80; KNTC2; NDC80; TID3
UniProt ID: (Human) O14777
Entrez Gene ID: (Human) 10403
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