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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:50 | - |
Immunocytochemistry (ICC/IF) |
0.25-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human HERC2 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.05 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2642394 |
Immunogen sequence: LTGASGNASG LPGVEALVGW LLDHSDIQVT ELSDADTVSD EYSDEEVVED MDDAAYSMST GAVVTESQTY K
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 85%.
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase HERC2; HECT domain and RCC1-like domain-containing protein 2; hect domain and RLD 2; HECT-type E3 ubiquitin transferase HERC2; HERC2; probable E3 ubiquitin-protein ligase HERC2
Gene Aliases: D15F37S1; HERC2; jdf2; MRT38; p528; SHEP1
UniProt ID: (Human) O95714
Entrez Gene ID: (Human) 8924
Molecular Function:
guanyl-nucleotide exchange factor
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