Immunogen sequence: MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL EDGEVYTCGL NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT TEDSVAVPRL IQKLNQQTIL QVSCGNWHCL ALAADGQFFT WGKNSHGQLG LGKEFPSQAS PQRVRSLEGI PLAQVAAGGA; Positive Samples: SH-SY5Y, U-87MG, A-431, Mouse lung, Mouse spinal cord; Cellular Location: Cytoplasm, Cytoplasmic vesicle
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: HECT domain and RCC1-like domain-containing protein 3; hect domain and RLD 3; HECT-type E3 ubiquitin transferase HERC3; Probable E3 ubiquitin-protein ligase HERC3
Gene Aliases: 5730409F18Rik; AI646603; HERC3; KIAA0032; mKIAA0032
UniProt ID: (Human) Q15034