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Immunogen sequence: GNASFGQLGLG GIDEEIVLEP RKSDFFINKR VRDVGCGLRH TVFVLDDGTV YTCGCNDLGQ LGHEKSRKKP EQV
Highest antigen sequence identity to the following orthologs - mouse 95%, rat 96%.
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HECT domain and RCC1-like domain-containing protein 4; hect domain and RLD 4; HECT-type E3 ubiquitin transferase HERC4; Probable E3 ubiquitin-protein ligase HERC4
Gene Aliases: HERC4; KIAA1593
UniProt ID: (Human) Q5GLZ8
Entrez Gene ID: (Human) 26091
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