The synthetic peptide sequence is 406-435aa, YYVNQSGIVTEKVKEIRDRIQRRAEELRNT
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
HERVs are a class of multiple sclerosis associated retroviruses. Reacts with a replication competent Human Endogenous Retrovirus (HERVW) isolated from placenta. The synthetic peptide sequence used as immunogen is taken from the virus envelope polyprotein sequence. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. The HERVW endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: endogenous retroviral family W, env(C7), member 1; Endogenous retrovirus group W member 1; endogenous retrovirus group W, member 1; Env-W; envelope glycoprotein; Envelope polyprotein gPr73; envelope protein; Enverin; gp24; gp50; HERV-7q Envelope protein; HERV-tryptophan envelope protein; HERV-W Env glycoprotein; HERV-W envelope protein; HERV-W_7q21.2 provirus ancestral Env polyprotein; human endogenous retrovirus W envC7-1 envelope protein; SU; Surface protein; Syncytin; syncytin A; Syncytin-1; TM; Transmembrane protein
Gene Aliases: ENV; ENVW; ERVW-1; ERVWE1; HERV-7q; HERV-W-ENV; HERV7Q; HERVW; HERVWENV
UniProt ID: (Human) Q9UQF0
Entrez Gene ID: (Human) 30816