FIGURE: 1 / 3
Sequence of this protein is as follows: MPADIMEKNS SSPVAASVNT TPDKPKTASE HRKSSKPIME KRRRARINES LSQLKTLILD ALKKDSSRHS KLEKADILEM TVKHLRNLQR AQMTAALSTD PSVLGKYRAG FSECMNEVTR FLSTCEGVNT EVRTRLLGHL ANCMTQINAM TYPGQPHPAL QAPPPPPPGP GGPQHAPFAP PPPLVPIPGG AAPPPGGAPC KLGSQAGEAA KVFGGFQVVP APDGQFAFLI PNGAFAHSGP VIPVYTSNSG TSVGPNAVSP SSGPSLTADS MWRPWRN
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
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Protein Aliases: bHLHb39; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1; Hairy homolog; Hairy-like; Hairy-like protein; hHL; Transcription factor HES-1
Gene Aliases: BHLHB39; HES-1; HES1; HHL; HL; HRY
Molecular Function: basic helix-loop-helix transcription factor