Search
Bioss
HEXB chain B Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
HEXB chain B Antibody (BS-15468R) in WB
Lane 1: Siha cell lysates; Lane 2: Mouse Bone lysates; Lane 3: Mouse Lymph node lysates probed with HEXB chain B Polyclonal Antibody, Unconjugated (bs-15468R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-15468R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HEXB chain B, amino acids 201-300.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: beta-hexosaminidase beta-subunit; Beta-hexosaminidase subunit beta; Beta-N-acetylhexosaminidase subunit beta; Cervical cancer proto-oncogene 7 protein; epididymis luminal protein 248; epididymis secretory protein Li 111; epididymis secretory sperm binding protein; HCC-7; hexosaminidase B (beta polypeptide); Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase prepro-polypeptide; N-acetyl-beta-glucosaminidase subunit beta
Gene Aliases: ENC-1AS; HCC7; HEL-248; HEL-S-111; HEXB
UniProt ID: (Human) P07686, (Mouse) P20060, (Rat) Q6AXR4
Entrez Gene ID: (Human) 3074, (Mouse) 15212, (Rat) 294673
hydrolase activity, hydrolyzing O-glycosyl compounds
beta-N-acetylhexosaminidase activity
protein binding
acetylglucosaminyltransferase activity
hexosaminidase activity
beta-N-acetylglucosaminidase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
carbohydrate binding
identical protein binding
macromolecular complex binding
protein homodimerization activity
protein heterodimerization activity
glycosidase
skeletal system development
carbohydrate metabolic process
N-acetylglucosamine metabolic process
N-glycan processing
lipid metabolic process
glycosphingolipid metabolic process
ganglioside catabolic process
cellular calcium ion homeostasis
lysosome organization
single fertilization
penetration of zona pellucida
sensory perception of sound
locomotory behavior
male courtship behavior
regulation of cell shape
phospholipid biosynthetic process
oligosaccharide catabolic process
regulation of metabolic process
lipid storage
sexual reproduction
glycosaminoglycan metabolic process
chondroitin sulfate catabolic process
dermatan sulfate catabolic process
hyaluronan catabolic process
myelination
astrocyte cell migration
positive regulation of transcription from RNA polymerase II promoter
oogenesis
neuromuscular process controlling balance
neuromuscular process
neuron cellular homeostasis
carbohydrate derivative metabolic process
metabolic process
regulation of cellular metabolic process
cellular protein metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support