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Proteintech
HEY1 Polyclonal Antibody
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Product Details
19929-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HEY1 Fusion Protein Ag13906 (155-295 aa encoded by BC001873)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VSHLNNYAS QREAASGAHA GLGHIPWGTV FGHHPHIAHP LLLPQNGHGN AGTTASPTEP HHQGRLGSAH PEAPALRAPP SGSLGPVLPV VTSASKLSPP LLSSVASLSA FPFSFGSFHL LSPNALSPSA PTQAANLGKP YR (155-295 aa encoded by BC001873)
Target Information
Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: basic helix loop helix factor; basic helix-loop-helix protein; basic helix-loop-helix protein OAF1; bHLHb31; Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HRT-1; HRT1; MGC1274; mHRT1; transcription factor; unnamed protein product
Gene Aliases: AI316788; AI414254; BHLHB31; CHF2; HERP2; hesr-1; HESR1; HEY1; hHRT1; HRT-1; HRT1; NERP2; OAF1
UniProt ID: (Human) Q9Y5J3
Entrez Gene ID: (Human) 23462, (Mouse) 15213, (Rat) 155437
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, protein binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
microsatellite binding
sequence-specific DNA binding
molecular_function
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
cardiac conduction system development
aortic valve morphogenesis
pulmonary valve morphogenesis
atrioventricular valve formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal aorta morphogenesis
umbilical cord morphogenesis
negative regulation of neuron differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
negative regulation of smooth muscle cell differentiation
cardiac epithelial to mesenchymal transition
heart trabecula formation
cardiac septum morphogenesis
ventricular septum morphogenesis
labyrinthine layer blood vessel development
arterial endothelial cell differentiation
negative regulation of biomineral tissue development
circulatory system development
regulation of vasculogenesis
blood vessel development
vasculogenesis
osteoblast development
outflow tract morphogenesis
atrioventricular valve morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion to mesenchymal transition involved in heart valve formation
ventricular trabecula myocardium morphogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
anterior/posterior axis specification
negative regulation of gene expression
mesenchymal cell development
positive regulation of osteoblast differentiation
artery development
Notch signaling involved in heart development
negative regulation of transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
cellular response to glucocorticoid stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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