Immunogen sequence: MKRPCEETTS ESDMDETIDV GSENNYSGQS TSSVIRLNSP TTTSQIMARK KRRGIIEKRR RDRINNSLSE LRRLVPTAFE KQGSAKLEKA EILQMTVDHL; Positive Samples: A-549, K562, MCF7, mouse brain, rat heart; Cellular Location: Nucleus
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.
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Protein Aliases: bHLHb32; cardiovascular basic helix-loop-helix factor 1; Cardiovascular helix-loop-helix factor 1; Class B basic helix-loop-helix protein 32; hairy and enhancer of split related 2; Hairy and enhancer of split-related protein 2; Hairy-E(spl)-related with YRPW motif 2; Hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; hes-related family bHLH transcription factor with YRPW motif 2; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hHRT2; HRT-2; mHRT2; Protein gridlock homolog
Gene Aliases: BHLHB32; CHF1; GRIDLOCK; GRL; HERP; HERP1; HESR2; HEY2; HRT2