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Abnova
HFE Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 3
HFE Antibody (H00003077-B01P) in WB
Western Blot analysis of HFE expression in transfected 293T cell line (H00003077-T01) by HFE MaxPab polyclonal antibody.
Lane 1: HFE transfected lysate(38.28 KDa).
Lane 2: Non-transfected lysate.
Lane 1: HFE transfected lysate(38.28 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00003077-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HFE (NP_000401.1, 1 a.a. approximately 348 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MGPRARPALL LLMLLQTAVL QGRLLRSHSL HYLFMGASEQ DLGLSLFEAL GYVDDQLFVF YDHESRRVEP RTPWVSSRIS SQMWLQLSQS LKGWDHMFTV DFWTIMENHN HSKESHTLQV ILGCEMQEDN STEGYWKYGY DGQDHLEFCP DTLDWRAAEP RAWPTKLEWE RHKIRARQNR AYLERDCPAQ LQQLLELGRG VLDQQVPPLV KVTHHVTSSV TTLRCRALNY YPQNITMKWL KDKQPMDAKE FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS PSGTLVIGVI SGIAVFVVIL FIGILFIILR KRQGSRGAMG HYVLAERE
Target Information
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin. It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hereditary hemochromatosis protein; hereditary hemochromatosis protein HLA-H; HFE 1; high Fe; HLA H; HLA-H; MGC10379; MGC103790; MGC:150812; MHC class I-like protein HFE; unnamed protein product
Gene Aliases: HFE; HFE1; HH; HLA-H; HLAH; MVCD7; TFQTL2
UniProt ID: (Human) Q30201
Entrez Gene ID: (Human) 3077
antigen processing and presentation of peptide antigen via MHC class I
regulation of T cell mediated immunity
negative regulation of T cell cytokine production
ion transport
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
cell surface receptor signaling pathway
response to iron ion
positive regulation of gene expression
antigen processing and presentation
BMP signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
transferrin transport
regulation of iron ion transport
hormone biosynthetic process
positive regulation of receptor-mediated endocytosis
positive regulation of SMAD protein import into nucleus
multicellular organismal iron ion homeostasis
protein-containing complex assembly
cellular response to iron ion
positive regulation of peptide hormone secretion
negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
response to iron ion starvation
regulation of protein localization to cell surface
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of CD8-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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