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HGF Polyclonal Antibody

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HGF Polyclonal Antibody

Product Details

BS-1025R

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Sheep, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human HGF alpha, amino acids 201-300.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Fibroblast derived tumor cytotoxic factor; fibroblast-derived tumor cytotoxic factor; Hepatocyte growth factor; Hepatocyte growth factor (hepapoietin A; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin A; hepatopoeitin-A; Hepatopoietin-A; HepatopoietinA; HGF; Lung fibroblast derived mitogen; lung fibroblast-derived mitogen; Scatter factor; scatter factor); SF; unnamed protein product

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Gene Aliases: C230052L06Rik; DFNB39; F-TCF; HGF; HGF/SF; HGFB; HPTA; NK1; NK2; SF; SF/HGF

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UniProt ID: (Human) P14210, (Mouse) Q08048, (Rat) P17945

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Entrez Gene ID: (Human) 3082, (Sheep) 443075, (Mouse) 15234, (Rat) 24446

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Function(s)
endopeptidase activity serine-type endopeptidase activity receptor binding protein binding growth factor activity chemoattractant activity identical protein binding protein heterodimerization activity serine protease
Process(es)
mitotic cell cycle cell morphogenesis epithelial to mesenchymal transition liver development proteolysis signal transduction negative regulation of autophagy skeletal muscle cell proliferation regulation of anatomical structure morphogenesis positive regulation of cell migration negative regulation of interleukin-6 production positive regulation of interleukin-10 production cellular response to hepatocyte growth factor stimulus negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway animal organ development epithelial cell proliferation negative regulation of inflammatory response positive chemotaxis regulation of multicellular organismal process myoblast proliferation positive regulation of protein kinase B signaling cell chemotaxis regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling negative regulation of release of cytochrome c from mitochondria regulation of p38MAPK cascade negative regulation of hydrogen peroxide-mediated programmed cell death negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of DNA biosynthetic process activation of MAPK activity cell proliferation positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of myelination negative regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis positive regulation of peptidyl-tyrosine phosphorylation positive regulation of neuron projection regeneration positive regulation of cell proliferation hyaluronan metabolic process organ regeneration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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