HGK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.
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Protein Aliases: epididymis secretory protein Li 31; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HPK/GCK-like kinase HGK; KIAA0687; MAP4K4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Mitogen-activated protein kinase kinase kinase kinase 4; Nck interacting kinase; Nck-interacting kinase; NIK; Ste20 group protein kinase HGK
Gene Aliases: FLH21957; HEL-S-31; HGK; KIAA0687; MAP4K4; MEKKK4; NIK
UniProt ID: (Human) O95819
Entrez Gene ID: (Human) 9448