HHEX is a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. Establishes anterior identity at two levels 1) acts early to enhance canonical WNT-signaling by repressing expression of TLE4 and 2) acts later to inhibit NODAL-signaling by directly targeting NODAL.
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Protein Aliases: hematopoietically expressed homeobox, related sequence 2; Hematopoietically-expressed homeobox protein HHEX; homeobox; Homeobox protein HEX; Homeobox protein PRH; homeobox, hematopoietically expressed; mHex; proline-rich homeodomain-containing transcription factor
Gene Aliases: HEX; Hex1; HHEX; Hhex-rs2; HMPH; HOX11L-PEN; PRH; PRHX
Molecular Function: homeodomain transcription factor