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      View (13) other HIF-2 alpha antibodies

      Invitrogen

      HIF-2 alpha Polyclonal Antibody

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      Catalog #:PA1-16510

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      Product Details

      TESTED APPLICATIONS DILUTION
      ChIP assay (ChIP) 1:10-1:500
      ELISA (ELISA) 1:100-1:2000
      Flow Cytometry (Flow) Assay-Dependent
      Gel Shift (GS) Assay-Dependent
      Immunocytochemistry (ICC) 1:100
      Immunofluorescence (IF) 1:100
      Immunohistochemistry (IHC) 1:100
      Immunohistochemistry (Paraffin) (IHC (P)) 1:100
      Immunoprecipitation (IP) 5 µg/1mg lysate
      Western Blot (WB) 1 µg/ml-2 µg/ml
      PUBLISHED APPLICATIONS
      Immunohistochemistry (IHC) See 1 publications below
      Miscellaneous PubMed (MISC) See 1 publications below
      Western Blot (WB) See 6 publications below
      Tested Species reactivity Fish, Hamster, Human, Mouse, Non-human primate, Sheep, Rat
      Published species reactivity Rat , Human
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen A peptide derived from the C-terminus of mouse/human HIF-2 alpha protein.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer PBS
      Contains 0.05% sodium azide
      Storage conditions 4° C, do not freeze
      RRID AB_2098236

      Product Specific Information

      Suggested positive control: Cos7 CoCl2-treated nuclear extract, PC12 nuclear extracts.

      Background/Target Information

      Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (8)

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      Bioinformatics

      Protein Aliases: Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; Endothelial pas domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; Hif like protein; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2 alpha; HIF-2-alpha; HIF-related factor; HIF1 alpha-like factor; HIF1alpha-like factor; HIF2 alpha; HIF2-alpha; HLF; HLF (HIF1alpha-like factor); HRF; Hypoxia inducible Factor 2 alpha; hypoxia inducible factor 2, alpha subunit; hypoxia inducible factor 2a; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; Member of pas superfamily 2; mHLF; MOP2; PAS domain-containing protein 2

      Gene Aliases: BHLHE73; ECYT4; EPAS1; HIF-2alpha; HIF2A; HLF; HRF; MOP2; PASD2

      UniProt ID: (Human) Q99814, (Rat) Q9JHS1, (Mouse) P97481

      Entrez Gene ID: (Human) 2034, (Rat) 29452, (Mouse) 13819

      Molecular Function: basic helix-loop-helix transcription factor nucleic acid binding transcription factor

      Suggested Secondary Antibodies

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