Keep as concentrated solution.
Predicted reactivity: Mouse (97%), Rat (95%), Xenopus laevis (86%), Pig (99%), Chicken (94%), Bovine (98%).
Positive Control: HepG2 (1% O2 treatment for 24hr), HT1080, 786-0, FADU.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
HIF-2 alpha (Epas1) is a transcription factor involved in the induction of genes regulated by oxygen. HIF-2 alpha contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. It also regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of the lungs. Mutations in this gene are associated with erythrocytosis familial type 4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; endothelial PAS domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2-alpha; hif-2a; HIF-2alpha; HIF2-alpha; HIF2A; HLF; hypoxia inducible factor 2 alpha; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; PAS domain-containing protein 2
Gene Aliases: BHLHE73; ECYT4; EPAS1; HIF2A; HLF; MOP2; PASD2; wu:fq36f01
UniProt ID: (Human) Q99814