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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid peptide near the center of the human HINT1.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||2.5 ug/ml|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is Jurkat cell lysate.
PA5-20613 can be used with blocking peptide PEP-0733.
Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5"e;-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
17 kDa inhibitor of protein kinase C; adenosine 5'-monophosphoramidase; HINT, PKCI-1, PRKCNH1; histidine triad nucleotide-binding protein 1; PKC inhibitor/ interacting protein; PKCI-1; protein kinase C inhibitor 1; protein kinase C, iota; protein kinase C-interacting protein 1
AA673479; HINT; HINT1; Ipk1; NMAN; Pkci; PKCI-1; PKCI1; Prkci; PRKCNH1