This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: NFLRASALSE HISPVVVIPA EASSPDSEPV LEKDDLMDMD ASQQNLFDNK FDDIFGSSFS SDPFNFNSQN GVNKDEKDHL IERLYREISG LKAQLENMKT ESQRVVLQLK GHVSELEADL AEQQHLRQQA ADDCEFLRAE LDELRRQRED
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIP I; HIP-1; HIP-I; hip1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I
Gene Aliases: 2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP-I; HIP1; ILWEQ; Kiaa4113; mKIAA4113; SHON; SHONbeta; SHONgamma