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Invitrogen
HIP1 Polyclonal Antibody
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FIGURE: 1 / 1
HIP1 Antibody (PA5-93288) in WB
Western blot analysis of HIP1 in extracts of various cell lines. Samples were incubated with HIP1 Polyclonal antibody (Product # PA5-93288) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-93288
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 410-690 of human HIP1 (NP_0053293)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
43 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SELEADLAEQ QHLRQQAADD CEFLRAELDE LRRQREDTEK AQRSLSEIER KAQANEQRYS KLKEKYSELV QNHADLLRKN AEVTKQVSMA RQAQVDLERE KKELEDSLER ISDQGQRKTQ EQLEVLESLK QELATSQREL QVLQGSLETS AQSEANWAAE FAELEKERDS LVSGAAHREE ELSALRKELQ DTQLKLASTE ESMCQLAKDQ RKMLLVGSRK AAEQVIQDAL NQLEEPPLIS CAGSADHLLS TVTSISSCIE QLEKSWSQYL ACPEDISGLL H; Positive Samples: A-549, BT-474, SW480, 293T, Mouse brain; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Endomembrane system, Nucleus, clathrin-coated vesicle membrane
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIP I; HIP-1; HIP-I; hip1; Huntingtin-interacting protein 1; Huntingtin-interacting protein I; novel variant; unnamed protein product
Gene Aliases: 2610109B09Rik; A930014B11Rik; E130315I21Rik; HIP-I; HIP1; ILWEQ; Kiaa4113; mKIAA4113; SHON; SHONbeta; SHONgamma
UniProt ID: (Human) O00291, (Mouse) Q8VD75
Entrez Gene ID: (Human) 3092, (Mouse) 215114
actin binding
epidermal growth factor receptor binding
structural constituent of cytoskeleton
protein binding
phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
clathrin binding
clathrin light chain binding
phosphatidylinositol-3-phosphate binding
phosphatidylinositol binding
glutamate receptor binding
AP-2 adaptor complex binding
clathrin adaptor activity
protein homodimerization activity
phosphatidylinositol-3,4-bisphosphate binding
protein heterodimerization activity
actin filament binding
phosphatidylinositol-3,5-bisphosphate binding
non-motor actin binding protein
endocytosis
apoptotic process
actin filament organization
regulation of endocytosis
cell differentiation
regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of receptor-mediated endocytosis
clathrin coat assembly
protein stabilization
positive regulation of protein kinase B signaling
apoptotic signaling pathway
regulation of postsynaptic neurotransmitter receptor internalization
presynaptic modulation of chemical synaptic transmission
neurotransmitter receptor transport
positive regulation of platelet-derived growth factor receptor-beta signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
activation of cysteine-type endopeptidase activity involved in apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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