Search
Invitrogen
HIP1R Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
HIP1R Antibody (PA5-30863) in ICC/IF
HIP1 Related antibody [N1N2], N-term detects HIP1R protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: HIP1R protein stained by HIP1 Related antibody [N1N2], N-term (Product # PA5-30863) diluted at 1:500. Blue: Hoechst 33343 staining.
Product Details
PA5-30863
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HIP1R. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: MCF-7.
Predicted reactivity: Mouse (96%), Rat (97%), Xenopus laevis (89%), Rabbit (95%), Chicken (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Huntingtin disease, a neurodegenerate disease, is caused by the expansion of a polymorphic glutamine tract in huntingtin. The Huntingtin Interacting Protein 1 (HIP-1) is a reportedly proapoptotic, cargo-specific adaptor protein that may be involved in the pathogenesis of Huntingtin disease. As well as playing a role in Huntingtin disease, it is likely to be involved in the recruitment of clathrin coats to lipid membranes and it may also factor in tumorigenesis by allowing the survival of precancerous and cancerous cells. Since HIP-1 expression is significantly associated with prostate and colon cancer metastasis, HIP-1 can serve as a putative prognostic factor for prostate and colon cancers.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: HIP-12; HIP1-related protein; huntingtin interacting protein 12; Huntingtin-interacting protein 1-related protein; Huntingtin-interacting protein 12; unnamed protein product
Gene Aliases: HIP12; HIP1R; HIP3; ILWEQ; KIAA0655
UniProt ID: (Human) O75146
Entrez Gene ID: (Human) 9026, (Rat) 81917
actin binding
protein binding
phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
SH3 domain binding
clathrin binding
clathrin light chain binding
phosphatidylinositol binding
clathrin adaptor activity
identical protein binding
protein homodimerization activity
phosphatidylinositol-3,4-bisphosphate binding
protein heterodimerization activity
actin filament binding
phosphatidylinositol-3,5-bisphosphate binding
protein binding, bridging
non-motor actin binding protein
endocytosis
receptor-mediated endocytosis
actin filament organization
regulation of endocytosis
negative regulation of actin filament polymerization
regulation of actin cytoskeleton organization
negative regulation of Arp2/3 complex-mediated actin nucleation
regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
clathrin coat assembly
protein stabilization
positive regulation of transport
positive regulation of cellular component organization
digestive system development
regulation of gastric acid secretion
membrane organization
apoptotic signaling pathway
intrinsic apoptotic signaling pathway
postsynapse organization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of clathrin coat assembly
regulation of clathrin-mediated endocytosis
positive regulation of platelet-derived growth factor receptor-beta signaling pathway
actin cytoskeleton organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support