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Bioss
HIP2 Polyclonal Antibody
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Product Details
BS-8379R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HIP2, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp564C1216; DKFZp686J24237; E2 ubiquitin-conjugating enzyme K; E2(25K); HIP-2; huntingtin interacting protein 2; Huntingtin-interacting protein 2; Ubiquitin carrier protein; ubiquitin conjugating enzyme E2K; Ubiquitin-conjugating enzyme E2 K; Ubiquitin-conjugating enzyme E2(25K); Ubiquitin-conjugating enzyme E2-25 kDa; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); Ubiquitin-protein ligase
Gene Aliases: AW492011; D5Ertd601e; E2-25K; HIP2; HYPG; LIG; UBC1; UBE2K
UniProt ID: (Human) P61086, (Mouse) P61087
Entrez Gene ID: (Human) 3093, (Mouse) 53323, (Rat) 289623
ubiquitin-protein transferase activity
protein binding
ATP binding
ubiquitin protein ligase binding
ubiquitin-ubiquitin ligase activity
nucleotide binding
ligase activity
ubiquitin protein ligase activity
ubiquitin conjugating enzyme activity
ubiquitin-like protein transferase activity
ubiquitin-protein ligase
ubiquitin-dependent protein catabolic process
positive regulation of peptidyl-threonine phosphorylation
free ubiquitin chain polymerization
regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to interferon-beta
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of type I interferon-mediated signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein K48-linked ubiquitination
protein polyubiquitination
protein ubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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