Fabgennix

HIPK2 Polyclonal Antibody, FITC

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HIPK2 Polyclonal Antibody, FITC

Product Details

HIPK2-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino aci region 860-910 on human Homeodomain-interacting protein kinase 3 protein.
View immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The HIPK2 gene encodes a member of the homeodomain-interacting protein kinase family, specifically a serine/threonine nuclear protein kinase. HIPK2 plays versatile roles in cellular processes, including transcription regulation, cell proliferation, differentiation, and apoptosis. It interacts with various transcription factors and proteins, contributing significantly to the modulation of gene expression. Notably, HIPK2 is involved in the activation of the tumor suppressor protein p53, with p53-dependent pro-apoptotic activity, positioning HIPK2 as a potential tumor suppressor gene. Recent studies highlight its downregulation in multiple tumor types and its emerging role in cancer biology and therapy. Its expression is subject to quality control mechanisms, including autophosphorylation at serine and threonine sites. Structurally, the crystal structure of HIPK2 reveals unique conformational attributes that contribute to its functionality in different signaling pathways. HIPK2's influence extends to physiological processes, such as fibrosis and central nervous system regulation, indicating its broad biological significance and potential therapeutic applications.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hHIPk2; Homeodomain-interacting protein kinase 2; Nuclear body-associated kinase 1; Sialophorin tail-associated nuclear serine/threonine-protein kinase

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Gene Aliases: 1110014O20Rik; B230339E18Rik; HIPK2; Nbak1; PRO0593; Stank

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UniProt ID: (Human) Q9H2X6, (Mouse) Q9QZR5

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Entrez Gene ID: (Human) 28996, (Rat) 362342, (Mouse) 15258

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Function(s)
RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcription corepressor activity protein kinase activity protein serine/threonine kinase activity protein binding ATP binding SMAD binding virion binding DNA binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of protein phosphorylation protein phosphorylation DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator transforming growth factor beta receptor signaling pathway smoothened signaling pathway adult walking behavior positive regulation of cell proliferation adult locomotory behavior anterior/posterior pattern specification retina layer formation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation neuron differentiation positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway positive regulation of protein binding intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of DNA binding negative regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade embryonic camera-type eye morphogenesis voluntary musculoskeletal movement positive regulation of sequence-specific DNA binding transcription factor activity embryonic retina morphogenesis in camera-type eye lens induction in camera-type eye SMAD protein signal transduction iris morphogenesis eye development transcription, DNA-templated modulation by virus of host morphology or physiology erythrocyte differentiation PML body organization regulation of cell cycle cellular response to hypoxia intrinsic apoptotic signaling pathway regulation of signal transduction by p53 class mediator regulation of transcription, DNA-templated apoptotic process cellular response to DNA damage stimulus phosphorylation negative regulation of nucleic acid-templated transcription
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