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Invitrogen
HIPPI Polyclonal Antibody
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FIGURE: 1 / 2
HIPPI Antibody (PA5-118002) in WB
Western Blot using HIPPI Polyclonal Antibody (Product # PA5-118002) at 1:500 dilution. Lane A: Raji Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary antibody: Goat Anti-Rabbit IgG (H+L)/HRP at 1:10,000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 49 kDa. Observed band size: 49 kDa. (We are unsure of the identity of these extra bands).
Product Details
PA5-118002
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived Human IFT57/HIPPI fragment
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dermal papilla-derived protein 8; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2
Gene Aliases: DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2
UniProt ID: (Human) Q9NWB7
Entrez Gene ID: (Human) 55081
neural tube closure
heart looping
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
smoothened signaling pathway
intraciliary transport
cilium assembly
regulation of apoptotic process
negative regulation of epithelial cell proliferation
left/right pattern formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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