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Invitrogen
HIPPI Polyclonal Antibody
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Product Details
PA5-19110
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (EQPQEYDDPNATISN ) corresponding to the internal amino acids of IFT57 (aa 103-117).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: death effector domain-containing protein; Dermal papilla-derived protein 8; ESRRBL1; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; huntingtin-interacting protein-1 protein interactor; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2; nuclear; unnamed protein product; Vestrogen-related receptor beta like 1
Gene Aliases: 4833420A15Rik; DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2; OFD18
UniProt ID: (Human) Q9NWB7, (Mouse) Q8BXG3
Entrez Gene ID: (Human) 55081, (Mouse) 73916
neural tube closure
heart looping
apoptotic process
smoothened signaling pathway
negative regulation of keratinocyte proliferation
intraciliary anterograde transport
intraciliary transport
regulation of apoptotic process
keratinocyte proliferation
motile cilium assembly
cilium morphogenesis
left/right pattern formation
non-motile cilium assembly
transcription, DNA-templated
regulation of transcription, DNA-templated
activation of cysteine-type endopeptidase activity involved in apoptotic process
cilium assembly
negative regulation of epithelial cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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