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Invitrogen
HIPPI Polyclonal Antibody
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Product Details
PA5-83275
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human IFT57. Recombinant protein control fragment (Product #RP-96303).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EGTGEVVLER GPGAAYHMFV VMEDLVEKLK LLRYEEEFLR KSNLKAPSRH YFALPTNPGE QFYMFCTLAA WLINKAGRPF EQPQEYDDPN
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: death effector domain-containing protein; Dermal papilla-derived protein 8; ESRRBL1; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2; nuclear; unnamed protein product
Gene Aliases: DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2; OFD18
UniProt ID: (Human) Q9NWB7
Entrez Gene ID: (Human) 55081
neural tube closure
heart looping
apoptotic process
smoothened signaling pathway
negative regulation of keratinocyte proliferation
intraciliary anterograde transport
intraciliary transport
regulation of apoptotic process
keratinocyte proliferation
motile cilium assembly
cilium morphogenesis
left/right pattern formation
non-motile cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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