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HIRA Polyclonal Antibody
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Product Details
BS-3530R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HIRA/DGGR1, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DiGeorge critical region gene 1; HIR histone cell cycle regulation defective homolog A; HIRA; HIRAHs; histone cell cycle regulation defective homolog A; histone regulator A; Protein HIRA; TUP1-like enhancer of split gene 1; TUP1-like enhancer of split protein 1; unnamed protein product
Gene Aliases: AA138857; D16Ertd95e; DGCR1; Gm15797; HIR; HIRA; N28177; OTTMUSG00000026264; TUP1; TUPLE1
UniProt ID: (Human) P54198, (Mouse) Q61666
Entrez Gene ID: (Human) 7290, (Mouse) 15260, (Rat) 363849
osteoblast differentiation
chromatin organization
nucleosome assembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
gastrulation
anatomical structure morphogenesis
muscle cell differentiation
negative regulation of transcription, DNA-templated
DNA replication-independent nucleosome assembly
chromatin modification
biological_process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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