Immunogen sequence: MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK; Positive Samples: SW480, BT-474; Cellular Location: Chromosome, Nucleus
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H2b 613; H2B histone family, member Q; H2B/q; histone 2, H2be; Histone H2B type 2-E; Histone H2B-GL105; Histone H2B.q; Histone H2Bq
Gene Aliases: AV127319; GL105; H2B; H2b-613; H2B.1; H2BFQ; H2BGL105; H2BQ; HIST2H2BE; T25626