Peptide sequence: FSYERSGYDL EESDGPDEDD NENEDDDEDS QAESVLSATP SVTASPQHLP
Sequence homology: Cow: 100%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 86%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%
This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes.
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Protein Aliases: Cirhin interaction protein; CIRIP; GAAP; Gate keeper of apoptosis-activating protein; HIV-EP1; Human immunodeficiency virus type I enhancer-binding protein 1; major histocompatibility complex binding protein 1; Major histocompatibility complex-binding protein 1; MBP-1; positive regulatory domain II binding factor 1; Positive regulatory domain II-binding factor 1; PRDII-BF1; Zinc finger protein 40
Gene Aliases: CIRIP; CRYBP1; GAAP; HIVEP1; MBP-1; PRDII-BF1; Schnurri-1; ZAS1; ZNF40; ZNF40A
UniProt ID: (Human) P15822
Entrez Gene ID: (Human) 3096