Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: IKADHVSTY AAFVQTHRPT GEFMFEFDED EQFYVDLDKK ETVWHLEEFG RAFSFEAQGG LANIAILNNN LNTLIQRSNH TQAANDPPEV TVFPKEPVEL GQPNTLICHI DRFFPPVLNV TWLCNGEPVT EGVAESLFLP RTDYSFHKFH YLTFVPSAED VYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETV (32-224 aa encoded by BC009956)
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DP(W3); DP(W4); HLA class II histocompatibility antigen, DP alpha 1 chain; HLA-SB alpha chain; MHC class II antigen; MHC class II DP3-alpha; MHC class II DPA1; MHC class II HLA-DPA1 antigen; Primed lymphocyte test-1
Gene Aliases: DP(W3); DP(W4); HLA-DP1A; HLA-DPA1; HLADP; HLASB; PLT1
UniProt ID: (Human) P20036
Entrez Gene ID: (Human) 3113
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