PA5-28046 targets HLA-DQB2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28046 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 231 of Human HLA-DQB2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.
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Protein Aliases: class II; DQ beta 2 (HLA-DXB)); DQ beta 2 chain; DV19.1 (major histocompatibility complex; DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)); DX beta chain; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen, DQ beta 2 chain; HLA class II histocompatibility antigen, DX beta chain; HLA-DQB1; HLA-DXB; major histocompatibility complex; major histocompatibility complex, class II, DQ beta 1; MHC class II antigen DQB2
Gene Aliases: HLA-DQB1; HLA-DQB2; HLA-DXB
UniProt ID: (Human) Q29870
Entrez Gene ID: (Human) 3120