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Invitrogen
HLA-DR/DP Polyclonal Antibody
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Product Details
PA5-103071
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HLA-DRB1(Accession P01911), corresponding to amino acid residues L15-E65.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total HLA-DRB1.
Target Information
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta1 domain MHC class II HLA DPB; class II HLA beta chain; DW2.2/DR2.2; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DP14-beta chain; HLA-D; HLA-DP histocompatibility type, beta-1 subunit; HLA-DR; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex class II antigen beta chain; MHC Class 2; MHC class II; MHC class II antigen; MHC class II antigen beta chain; MHC class II antigen DP beta 1 chain; MHC class II antigen DPB1; MHC class II antigen DPbeta1; MHC class II HLA-DP-beta-1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRB1; MHC class II HLA-DRw10-beta; MHC HLA DPB1; MHC HLA-D; MHC II HLA
Gene Aliases: DPB1; DRB1; DRw10; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DR1B; HLA-DRB; HLA-DRB1; SS1
UniProt ID: (Human) Q29684, (Human) Q4PRC3
Entrez Gene ID: (Human) 3115, (Human) 3123
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
T cell receptor signaling pathway
positive regulation of T cell activation
interferon-gamma-mediated signaling pathway
polysaccharide assembly with MHC class II protein complex
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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