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Proteintech
HLA-DRA Polyclonal Antibody
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Product Details
17221-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HLA-DRA Fusion Protein Ag11044 (24-218 aa encoded by BC032350)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WAIKEEHVI IQAEFYLNPD QSGEFMFDFD GDEIFHVDMA KKETVWRLEE FGRFASFEAQ GALANIAVDK ANLEIMTKRS NYTPITNVPP EVTVLTNSPV ELREPNVLIC FIDKFTPPVV NVTWLRNGKP VTTGVSETVF LPREDHLFRK FHYLPFLPST EDVYDCRVEH WGLDEPLLKH WEFDAPSPLP ETTENV (24-218 aa encoded by BC032350)
Target Information
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; HLA-DR alpha-chain; hla-dr antigen alpha chain; hla-dr antigen heavy chain; HLA-DR-alpha chain precursor; HLA-DRA; MHC class II antigen DRA; unnamed protein product
Gene Aliases: HLA-DRA; HLA-DRA1
UniProt ID: (Human) P01903
Entrez Gene ID: (Human) 3122
positive regulation of T cell mediated cytotoxicity
adaptive immune response
immune system process
myeloid dendritic cell antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class II
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of memory T cell differentiation
regulation of T-helper cell differentiation
positive regulation of immune response
positive regulation of T cell activation
cognition
positive regulation of CD4-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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