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HLA-DRB (MHC II) Recombinant Rabbit Monoclonal Antibody (MSVA-478R)

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HLA-DRB (MHC II) Recombinant Rabbit Monoclonal Antibody (MSVA-478R)

Product Details

3123-RBM10-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

MSVA-478R

Immunogen

Recombinant full-length human HLA-DRB1 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product cellular localization: Cell membrane.

Positive control: Liver: An at least moderate staining should be seen of sinusoids and Kupffer cells. Kidney: An at least moderate staining should be seen in small capillaries of glomeruli.

Tissue specificity: Expressed in professional APCs: macrophages, dendritic cells and B cells (at protein level) (PubMed:31495665, PubMed:15322540, PubMed:23783831). Expressed in thymic epithelial cells (at protein level) (PubMed:23783831).

Target Information

HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DAMC-146E17.2; DR beta-5; DR2-beta-2; DR7 beta-chain glycoprotein; DRB1; DRB52; DRw53 beta-chain glycoprotein; Dw2; ERLA-005; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DRB3; HLA-DR-beta chain; HLA-DR11-14N allele; HLA-DRB1; human leucocyte antigen; human leucocyte antigen DRB1; human leucocyte antigen DRB3; Human leukocyte antigen DRB1; leukocyte antigen; lymphocyte antigen DRB1; major histocompatibility complex, class II, DRB3; MHC class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II DR beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR4 protein; MHC class II HLA-DR4/w53 protein; MHC class II protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-1 chain; MHC DR7-beta-2 chain; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-DR-beta chain; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta surface glycoprotein; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-1 precursor; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)a glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)a glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DR2(non-Dw2/non-Dw12)a glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; unnamed protein product

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Gene Aliases: DR4; DRB1; DRB3; DRB4; DRB5; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB3*; HLA-DRB4; HLA-DRB4*; HLA-DRB5; HLA-DRB5*; SS1

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UniProt ID: (Human) P01911, (Human) P79483, (Human) P13762, (Human) Q30154

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Entrez Gene ID: (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127

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Function(s)
structural constituent of cytoskeleton protein binding MHC class II protein complex binding polysaccharide binding MHC class II receptor activity peptide antigen binding T cell receptor binding CD4 receptor binding
Process(es)
adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of immune response positive regulation of T cell activation myeloid dendritic cell antigen processing and presentation positive regulation of T cell mediated immune response to tumor cell signal transduction T cell receptor signaling pathway positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation inflammatory response to antigenic stimulus antigen processing and presentation of endogenous peptide antigen via MHC class II negative regulation of inflammatory response to antigenic stimulus humoral immune response cytoskeleton organization epidermis development detection of bacterium macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of kinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of memory T cell differentiation positive regulation of MAPK cascade regulation of T-helper cell differentiation positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell protein tetramerization positive regulation of ERK1 and ERK2 cascade
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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