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HLA-DRB1 Polyclonal Antibody

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HLA-DRB1 Polyclonal Antibody

Product Details

15862-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Flow Cytometry (Flow)

Assay-dependent
-

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HLA-DRB1 Fusion Protein Ag8405 (31-227 aa encoded by BC007920)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Amount

52.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DTRPRFLEY STSECHFFNG TERVRFLDRY FHNQEENVRF DSDVGEFRAV TELGRPDAEY WNSQKDILED ERAAVDTYCR HNYGVGESFT VQRRVHPKVT VYPSKTQPLQ HHNLLVCSVS GFYPGSIEVR WFRNGQEEKT GVVSTGLIHN GDWTFQTLVM LETVPRSGEV YTCQVEHPSV TSPLTVEWRA RSESAQSK (31-227 aa encoded by BC007920 )

Target Information

HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DRB52; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-DR-beta chain; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; lymphocyte antigen DRB1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR4 protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-2 chain; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; unnamed protein product

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Gene Aliases: DRB1; HLA-DR1B; HLA-DRB; HLA-DRB1; SS1

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UniProt ID: (Human) P01911

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Entrez Gene ID: (Human) 3123

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Function(s)
structural constituent of cytoskeleton protein binding MHC class II protein complex binding polysaccharide binding MHC class II receptor activity peptide antigen binding T cell receptor binding CD4 receptor binding
Process(es)
positive regulation of T cell mediated cytotoxicity positive regulation of protein phosphorylation adaptive immune response immune system process inflammatory response to antigenic stimulus myeloid dendritic cell antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of T cell mediated immune response to tumor cell negative regulation of inflammatory response to antigenic stimulus immune response humoral immune response cytoskeleton organization signal transduction epidermis development detection of bacterium antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of kinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of memory T cell differentiation positive regulation of MAPK cascade regulation of T-helper cell differentiation positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell positive regulation of immune response T cell receptor signaling pathway positive regulation of T cell activation protein tetramerization positive regulation of ERK1 and ERK2 cascade positive regulation of CD4-positive, alpha-beta T cell activation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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