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Invitrogen
HLA-DRB3 Polyclonal Antibody
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Product Details
PA5-85209
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HLA-DRB3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain ( beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DR7 beta-chain glycoprotein; HLA class II histocompatibility antigen, DR beta 3 chain; HLA DR3B; HLA DRB3; human leucocyte antigen DRB3; leukocyte antigen; major histocompatibility complex, class II, DRB3; MGC117330; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II DR beta chain; MHC class II HLA-DR beta 3 chain; MHC class II protein; unnamed protein product
Gene Aliases: DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3; HLA-DRB3*
UniProt ID: (Human) P79483
Entrez Gene ID: (Human) 3125
adaptive immune response
immune system process
myeloid dendritic cell antigen processing and presentation
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
positive regulation of T cell mediated immune response to tumor cell
immune response
signal transduction
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of CD4-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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