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Product Details
14046-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HLCS Fusion Protein Ag5208 (425-726 aa encoded by BC060787)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: SYVSEVEIT PSCIPVVTNM EAFSSEHFNL EIYRQNLQTK QLGKVILFAE VTPTTMRLLD GLMFQTPQEM GLIVIAARQT EGKGRGGNVW LSPVGCALST LLISIPLRSQ LGQRIPFVQH LMSVAVVEAV RSIPEYQDIN LRVKWPNDIY YSDLMKIGGV LVNSTLMGET FYILIGCGFN VTNSNPTICI NDLITEYNKQ HKAELKPLRA DYLIARVVTV LEKLIKEFQD KGPNSVLPLY YRYWVHSGQQ VHLGSAEGPK VSIVGLDDSG FLQVHQEGGE VVTVHPDGNS FDMLRNLILP KRR (425-726 aa encoded by BC060787)
Target Information
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Biotin apo-protein ligase; biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase; Biotin--[acetyl-CoA-carboxylase] ligase; Biotin--[methylcrotonoyl-CoA-carboxylase] ligase; Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase; HCS; Holocarboxylase synthetase; holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase); holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
Gene Aliases: 410I21.SP6; D16Jhu34; HCS; HLCS; RGD1565360
UniProt ID: (Human) P50747, (Mouse) Q920N2
Entrez Gene ID: (Human) 3141, (Rat) 288240, (Mouse) 110948
Molecular Function:
ligase
biotin-[acetyl-CoA-carboxylase] ligase activity
biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
protein binding
ATP binding
biotin binding
biotin-protein ligase activity
enzyme binding
protein homodimerization activity
nucleotide binding
catalytic activity
ligase activity
lipoate-protein ligase activity
tRNA(Ile)-lysidine synthase activity
biotin-[pyruvate-carboxylase] ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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