FIGURE: 1 / 4
Immunogen sequence: SYVSEVEIT PSCIPVVTNM EAFSSEHFNL EIYRQNLQTK QLGKVILFAE VTPTTMRLLD GLMFQTPQEM GLIVIAARQT EGKGRGGNVW LSPVGCALST LLISIPLRSQ LGQRIPFVQH LMSVAVVEAV RSIPEYQDIN LRVKWPNDIY YSDLMKIGGV LVNSTLMGET FYILIGCGFN VTNSNPTICI NDLITEYNKQ HKAELKPLRA DYLIARVVTV LEKLIKEFQD KGPNSVLPLY YRYWVHSGQQ VHLGSAEGPK VSIVGLDDSG FLQVHQEGGE VVTVHPDGNS FDMLRNLILP KRR (425-726 aa encoded by BC060787)
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
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Protein Aliases: Biotin apo-protein ligase; biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase; Biotin--[acetyl-CoA-carboxylase] ligase; Biotin--[methylcrotonoyl-CoA-carboxylase] ligase; Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase; HCS; Holocarboxylase synthetase; holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase); holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
Gene Aliases: 410I21.SP6; D16Jhu34; HCS; HLCS; RGD1565360
Molecular Function: ligase