This target displays homology in the following species: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 92%
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hIMP1; Minor histocompatibility antigen H13; presenilin-like aspartyl protease; Presenilin-like protein 3; Signal peptide peptidase; signal peptide peptidase beta
Gene Aliases: 1200006O09Rik; 4930443L17Rik; 5031424B04Rik; AV020344; H-13; H13; Hm13; PSL3; Spp
UniProt ID: (Mouse) Q9D8V0
Entrez Gene ID: (Mouse) 14950
Molecular Function: aspartic protease