Invitrogen

HMG20A Polyclonal Antibody

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HMG20A Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of paraffin embedded of Human Spleen using Product # PA5-18087 at a concentration of 2.5 µg/mL. The tissue was processed by steamed antigen retrieval with citrate buffer pH 6 and stained with AP.

Product Details

PA5-18087

Applications	Tested Dilution	Publications
Western Blot (WB)	Assay-dependent	-
Immunohistochemistry (IHC)	1-2 µg/mL	-
Immunohistochemistry (Paraffin) (IHC (P))	1-2 µg/mL	-

Product Specifications
Species Reactivity	Human, Rat
Host/Isotype	Goat / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Synthetic peptide sequence (ATVREVVNRLDR) corresponding to the C-terminus amino acids of HMG20A
Conjugate	Unconjugated
Form	Liquid
Concentration	0.5 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	TBS, pH 7.3, with 0.5% BSA
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_10979707

Product Specific Information

This antibody is predicted to react with bovine, canine, mouse and porcine based on sequence homology.

Target Information

Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ10739; High mobility group protein 20A; HMG box domain containing 1; HMG box-containing protein 20A; HMG domain-containing protein 1; HMG domain-containing protein HMGX1

Gene Aliases: HMG20A; HMGX1; HMGXB1; RGD1564760

UniProt ID: (Human) Q9NP66

Entrez Gene ID: (Human) 10363, (Rat) 315689

Function(s)

negative regulation of transcription from RNA polymerase II promoter chromatin remodeling regulation of transcription, DNA-templated chromatin modification negative regulation of neuron differentiation chromatin organization transcription, DNA-templated covalent chromatin modification

Process(es)

DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein heterodimerization activity chromatin binding