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Abnova
HMGA1 Polyclonal Antibody, MaxPab™
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Product Details
H00003159-B03P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HMGA1 (NP_665906.1, 1 a.a. approximately 107 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ
Target Information
HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:5010; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; High mobility group protein R; high-mobility-group protein isoform I; HMG-I(Y); HMG-R; differentially spliced form of HMG-I(Y); isoform Y; MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y; OTTHUMP00000016222; OTTHUMP00000016223; OTTHUMP00000016224; OTTHUMP00000039618; unnamed protein product
Gene Aliases: HMG-R; HMGA1; HMGA1A; HMGIY
UniProt ID: (Human) P17096
Entrez Gene ID: (Human) 3159
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcription cofactor binding
DNA binding
AT DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
RNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
DNA binding, bending
enzyme binding
structural constituent of chromatin
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
retinoid X receptor binding
5'-deoxyribose-5-phosphate lyase activity
binding, bridging
molecular function activator activity
base-excision repair
nucleosome disassembly
regulation of transcription, DNA-templated
negative regulation of cell proliferation
regulation of gene expression
positive regulation of macromolecule biosynthetic process
intracellular signal transduction
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
oncogene-induced cell senescence
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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