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Invitrogen
HMGA1B Polyclonal Antibody
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Product Details
PA5-149106
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human HMGA1B, Met1-Glu96
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
HMGA1B (High Mobility Group AT-Hook 1B) is a gene that encodes a member of the high mobility group A (HMGA) family of proteins, which are known for their role in regulating chromatin structure and gene expression. HMGA1B proteins are characterized by their AT-hook motifs, which allow them to bind to the minor groove of AT-rich regions in DNA. This binding can influence the architecture of chromatin, thereby modulating the access of transcription factors and other regulatory proteins to DNA. HMGA1B is implicated in various cellular processes, including differentiation, proliferation, and apoptosis. Overexpression or dysregulation of HMGA1B is often associated with tumorigenesis and has been observed in numerous cancers, such as breast, prostate, and pancreatic cancers. This protein can promote oncogenic transformation by altering the expression of genes involved in cell growth and survival. Additionally, HMGA1B has been linked to metabolic disorders and developmental abnormalities. Understanding the function and regulation of HMGA1B is crucial for developing targeted therapies aimed at modulating its activity in cancer and other diseases. Research into HMGA1B provides valuable insights into its role in chromatin dynamics and gene regulation, highlighting its potential as a therapeutic target and biomarker for disease diagnosis and prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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