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Invitrogen

HMGB2 Polyclonal Antibody

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HMGB2 Polyclonal Antibody

Product Details

PA5-85575

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human HMGB2. The exact sequence is proprietary.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792715

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (100%), Bovine (100%).

Positive Control: 293T, A431, HeLa, HepG2, HMGB2-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

HMGB2 encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: High mobility group protein 2; High mobility group protein B2; high-mobility group (nonhistone chromosomal) protein 2; HMG 2; HMG B2; HMG-2; HMG-B2; HMGB-2; unnamed protein product

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Gene Aliases: HMG2; HMGB2

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UniProt ID: (Human) P26583

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Entrez Gene ID: (Human) 3148

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Function(s)
four-way junction DNA binding transcription regulatory region sequence-specific DNA binding core promoter proximal region sequence-specific DNA binding DNA binding damaged DNA binding double-stranded DNA binding single-stranded DNA binding transcription coactivator activity RNA binding protein binding transcription factor binding DNA binding, bending protein domain specific binding chemoattractant activity non-sequence-specific DNA binding, bending RAGE receptor binding supercoiled DNA binding DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of endothelial cell proliferation immune system process inflammatory response to antigenic stimulus DNA topological change double-strand break repair via nonhomologous end joining DNA recombination chromatin organization nucleosome assembly chromatin remodeling regulation of transcription from RNA polymerase II promoter chemotaxis inflammatory response spermatogenesis spermatid nucleus differentiation male gonad development extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression negative regulation of gene expression DNA geometric change response to lipopolysaccharide positive regulation of interferon-beta production V(D)J recombination innate immune response positive regulation of innate immune response positive regulation of erythrocyte differentiation positive regulation of megakaryocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone regulation of neurogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium positive chemotaxis cell chemotaxis cellular response to lipopolysaccharide regulation of stem cell proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of hemopoiesis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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