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Invitrogen
HMGCR Polyclonal Antibody
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Product Details
PA5-116698
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 351-440 of HMGCR (NP_0008501)
Conjugate
Form
Liquid
Concentration
0.78 mg/mL
Amount
78 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: 293T, K-562
Immunogen sequence: KNPITSPVVT QKKVPDNCCR REPMLVRNNQ KCDSVEEETG INRERKVEVI KPLVAETDTP NRATFVVGNS SLLDTSSVLV TQEPEIELPR
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl coenzyme A reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269; unnamed protein product
Gene Aliases: 3H3M; HMG-CoAR; HMGCR; LDLCQ3; LGMDR28; MYPLG; Red
UniProt ID: (Human) P04035, (Mouse) Q01237, (Rat) P51639
Entrez Gene ID: (Human) 3156, (Mouse) 15357, (Rat) 25675
hydroxymethylglutaryl-CoA reductase (NADPH) activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GTPase regulator activity
NADP binding
NADPH binding
coenzyme A binding
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
coenzyme binding
protein phosphatase 2A binding
oxidoreductase
reductase
metabolite interconversion enzyme
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
steroid metabolic process
cholesterol metabolic process
isoprenoid biosynthetic process
visual learning
coenzyme A metabolic process
sterol biosynthetic process
negative regulation of protein catabolic process
negative regulation of protein secretion
long-term synaptic potentiation
regulation of ERK1 and ERK2 cascade
negative regulation of beta-amyloid clearance
ubiquinone metabolic process
positive regulation of cell proliferation
embryo development
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
positive regulation of stress-activated MAPK cascade
negative regulation of apoptotic process
negative regulation of MAP kinase activity
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade
aging
response to nutrient
farnesyl diphosphate biosynthetic process, mevalonate pathway
myoblast differentiation
response to ethanol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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