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Bethyl Laboratories
HMGN1 Polyclonal Antibody
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FIGURE: 1 / 3
HMGN1 Antibody (A302-363A) in IHC (P)
Detection of human and mouse HMGN1 by immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-HMGN1 (Product # A302-363A) (Lot 1) used at a dilution of 1:5,000 (0.2 µg/mL). Detection: DAB.
Product Details
A302-363A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 90 and 100 of human high-mobility group nucleosome binding domain 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription. HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates. HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence. Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber. In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ27265; FLJ31471; High mobility group nucleosome-binding domain-containing protein 1; high mobility group protein 14; high-mobility group (nonhistone chromosomal) protein 14; high-mobility group nucleosome binding 1; high-mobility group nucleosome-binding domain-containing protein 1; HMG 14; HMGN 1; MGC104230; MGC117425; Non-histone chromosomal protein HMG-14; nonhistone chromosomal protein HMG-14; unnamed protein product
Gene Aliases: HMG-14; HMG14; HMGN1
UniProt ID: (Human) P05114, (Mouse) P18608
Entrez Gene ID: (Human) 3150, (Mouse) 15312
pyrimidine dimer repair by nucleotide-excision repair
transcription-coupled nucleotide-excision repair
chromatin organization
regulation of transcription from RNA polymerase II promoter
response to UV-B
response to UV-C
positive regulation of DNA-templated transcription, elongation
regulation of development, heterochronic
post-embryonic camera-type eye morphogenesis
regulation of epithelial cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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