This is a rabbit polyclonal antibody raised against the N-terminal region of human HNF1B. HNF1B exists some isoforms with MW of 61 kDa, 58 kDa, 46 kDa, and 44 kDa.
Hepatocyte Nuclear Factor 1 (HNF1, Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) is a member of the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1has been shown to function in nephron development and regulates development of the embryonic pancreas. Mutations in the gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF-1-beta; HNF-1B; HNF1 beta A; Homeoprotein LFB3; TCF-2; Transcription factor 2; Transcription factor 2 hepatic; Transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor; Transcription factor 2, hepatic; Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor; Variant hepatic nuclear factor 1; vHNF1
Gene Aliases: FJHN; HNF-1-beta; HNF-1B; HNF-1Beta; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
Molecular Function: DNA-binding transcription factor