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Proteintech
HNRNPL Polyclonal Antibody
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Product Details
18354-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Bovine,
Hamster,
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HNRNPL Fusion Protein Ag13211 (210-572 aa encoded by BC069184)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody may recognize both isoforms of the hnRNP L protein.
Immunogen sequence: FRKNGVQAM VEFDSVQSAQ RAKASLNGAD IYSGCCTLKI EYAKPTRLNV FKNDQDTWDY TNPNLSGQGD PGSNPNKRQR QPPLLGDHPA EYGGPHGGYH SHYHDEGYGP PPPHYEGRRM GPPVGGHRRG PSRYGPQYGH PPPPPPPPEY GPHADSPVLM VYGLDQSKMN CDRVFNVFCL YGNVEKVKFM KSKPGAAMVE MADGYAVDRA ITHLNNNFMF GQKLNVCVSK QPAIMPGQSY GLEDGSCSYK DFSESRNNRF STPEQAAKNR IQHPSNVLHF FNAPLEVTEE NFFEICDELG VKRPSSVKVF SGKSERSSSG LLEWESKSDA LETLGFLNHY QMKNPNGPYP YTLKLCFSTA QHAS (210-572 aa encoded by B C069184)
Target Information
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ35509; Heterogeneous nuclear ribonucleoprotein L; hnRNP L; unnamed protein product
Gene Aliases: C79783; D830027H13Rik; hnRNP-L; HNRNPL; HNRPL; P/OKcl.14
UniProt ID: (Human) P14866, (Mouse) Q8R081
Entrez Gene ID: (Human) 3191, (Mouse) 15388
mRNA processing
cellular response to amino acid starvation
positive regulation of translation
negative regulation of mRNA splicing, via spliceosome
positive regulation of mRNA binding
regulation of alternative mRNA splicing, via spliceosome
RNA processing
regulation of RNA splicing
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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