Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).
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Protein Aliases: E3 ubiquitin-protein ligase RNF31; HOIL 1 interacting protein; HOIL-1-interacting protein; HOIP; PAUL; Putative Ariadne-like ubiquitin ligase; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; RNF31; ZIBRA; Zinc in-between-RING-finger ubiquitin-associated domain protein
Gene Aliases: AL033293; BC031509; Flj10111; HOIP; mFLJ00217; Paul; RNF31; ZIBRA