Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
16289-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HOIP Fusion Protein Ag9440 (258-603 aa encoded by BC017376)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RQHFTIALK EKHITDMVCP ACGRPDLTDD TQLLSYFSTL DIQLRESLEP DAYALFHKKL TEGVLMRDPK FLWCAQCSFG FIYEREQLEA TCPQCHQTFC VRCKRQWEEQ HRGRSCEDFQ NWKRMNDPEY QAQGLAMYLQ ENGIDCPKCK FSYALARGGC MHFHCTQCRH QFCSGCYNAF YAKNKCPEPN CRVKKSLHGH HPRDCLFYLR DWTALRLQKL LQDNNVMFNT EPPAGARAVP GGGCRVIEQK EVPNGLRDEA CGKETPAGYA GLCQAHYKEY LVSLINAHSL DPATLYEVEE LETATERYLH VRPQPLAGED PPAYQARLLQ KLTEEVPLGQ SIPRRRK (258-603 aa encoded by BC017376 )
Target Information
Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RNF31; FLJ23501; HOIL-1-interacting protein; HOIP; MGC19975; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; Zinc in-between-RING-finger ubiquitin-associated domain protein
Gene Aliases: HOIP; RNF31; ZIBRA
UniProt ID: (Human) Q96EP0
Entrez Gene ID: (Human) 55072
protein polyubiquitination
I-kappaB kinase/NF-kappaB signaling
regulation of tumor necrosis factor-mediated signaling pathway
CD40 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
protein linear polyubiquitination
positive regulation of protein targeting to mitochondrion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support