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Proteintech
HOIP Polyclonal Antibody
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Product Details
16289-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HOIP Fusion Protein Ag9440 (258-603 aa encoded by BC017376)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RQHFTIALK EKHITDMVCP ACGRPDLTDD TQLLSYFSTL DIQLRESLEP DAYALFHKKL TEGVLMRDPK FLWCAQCSFG FIYEREQLEA TCPQCHQTFC VRCKRQWEEQ HRGRSCEDFQ NWKRMNDPEY QAQGLAMYLQ ENGIDCPKCK FSYALARGGC MHFHCTQCRH QFCSGCYNAF YAKNKCPEPN CRVKKSLHGH HPRDCLFYLR DWTALRLQKL LQDNNVMFNT EPPAGARAVP GGGCRVIEQK EVPNGLRDEA CGKETPAGYA GLCQAHYKEY LVSLINAHSL DPATLYEVEE LETATERYLH VRPQPLAGED PPAYQARLLQ KLTEEVPLGQ SIPRRRK (258-603 aa encoded by BC017376 )
Target Information
Lyn proto oncogene (Lcl/Yes related novel protein tyrosine kinase) is encoded by the Lyn gene located on chromosome 8 in humans and belongs to the Src family kinase. It is a non-receptor tyrosine kinase that acts as a mediator in transducing cellular signaling. The most well studied expression of Lyn is in hematopoietic cell types, both lymphoid and myeloid cells with exclusion in T lymphocytes. It has also been observed that Lyn plays diverse roles such as in regulation of B cell receptor signaling, mast cell signaling and Epithelial - Mesenchymal Transition (EMT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RNF31; FLJ23501; HOIL-1-interacting protein; HOIP; MGC19975; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31; unnamed protein product; Zinc in-between-RING-finger ubiquitin-associated domain protein
Gene Aliases: HOIP; IMD115; Paul; RNF31; ZIBRA
UniProt ID: (Human) Q96EP0
Entrez Gene ID: (Human) 55072
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ubiquitin protein ligase binding
K48-linked polyubiquitin binding
identical protein binding
ubiquitin binding
metal ion binding
ubiquitin protein ligase activity
K63-linked polyubiquitin binding
linear polyubiquitin binding
protein polyubiquitination
cell surface receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
protein ubiquitination
CD40 signaling pathway
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
T cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
negative regulation of necroptotic process
protein linear polyubiquitination
positive regulation of protein targeting to mitochondrion
positive regulation of xenophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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