Proteintech

HOPX Polyclonal Antibody

HOPX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HOPX Antibody (11419-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using 11419-1-AP ( HOPX Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

HOPX Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11419-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 10 publications 10 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HOPX Fusion Protein Ag1979 (1-73 aa encoded by BC014225)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSAETASGP TEDQVEILEY NFNKVDKHPD STTLCLIAAE AGLSEEETQK WFKQRLAKWR RSEGLPSECR SVID (1-73 aa encoded by BC014225)

Target Information

HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX.

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Human alveolar progenitors generate dual lineage bronchioalveolar organoids.

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Wang W,Su L,Ji F,Zhang D,Wang Y,Zhao J,Jiao RD,Zhang M,Huang E,Jiang H,Zhang J,Jiao J

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Song H,Chen S,Zhang T,Huang X,Zhang Q,Li C,Chen C,Chen S,Liu D,Wang J,Tu Y,Wu Y,Liu Y

Sat Mar 19 00:00:00 EDT 2022

Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes.

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Yang L,Li Z,Liu G,Li X,Yang Z

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Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

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Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.

eLife

Cebrian-Silla A,Nascimento MA,Redmond SA,Mansky B,Wu D,Obernier K,Romero Rodriguez R,Gonzalez-Granero S,García-Verdugo JM,Lim DA,Álvarez-Buylla A

Wed Jul 14 00:00:00 EDT 2021

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.

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Mon Jan 18 00:00:00 EST 2021

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Cell stress in cortical organoids impairs molecular subtype specification.

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