This target displays homology in the following species: Cow: 93%; Dog: 86%; Guinea Pig: 83%; Horse: 92%; Human: 93%; Mouse: 100%; Pig: 93%; Rabbit: 85%; Rat: 93%
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
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