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HOXB5 Polyclonal Antibody
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Product Details
BS-6668R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HOXB5, amino acids 181-269.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The Hox proteins are a family of transcription factors that play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. Hox proteins are involved in controlling axial patterning, leukemias and hereditary malformations. HoxB5 (homeobox protein Hox-B5), also known as HOX2, HU-1, HOX2A, Hox2.1 or HHO.C10, is a member of the Antp homeobox (Hox) family. It is a 269 amino acid long nuclear protein expressed in the central nervous system. HoxB5 contains one homeobox DNAbinding domain and plays a role in the regulation of lung and gut development, providing cells with positional identities on the anterior-posterior body axis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 2A; homeo box B5; Homeobox protein H24.1; Homeobox protein HHO.C10; Homeobox protein Hox-2.1; Homeobox protein Hox-2A; Homeobox protein Hox-B5; Homeobox protein Hu-1; Homeobox protein Mu-1; unnamed protein product
Gene Aliases: AI385717; HHO.C10; Hox-2.1; HOX2; Hox2.1; HOX2A; Hoxb-5; HOXB5; HU-1; RGD1562292
UniProt ID: (Human) P09067, (Mouse) P09079
Entrez Gene ID: (Human) 3215, (Rat) 497987, (Mouse) 15413
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
sequence-specific DNA binding
homeodomain transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
anatomical structure morphogenesis
anterior/posterior pattern specification
endothelial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
embryonic skeletal system development
transcription from RNA polymerase II promoter
transcription, DNA-templated
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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